217065
uPAR (Urokinase-type Plasminogen Activator Receptor)
Size
£691.00
- SKU:
- 217065
- Purity:
- Purified by Protein G affinity chromatography from culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to human uPAR EC domain.
- Clone:
- 14L968
- Format:
- Supplied as a lyophilized powder in PBS. Reconstitute with 200ul of sterile PBS.
- Extra Details:
- uPAR (Urokinase plasminogen activator receptor) is a 55kD glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum b-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis. Applications: Suitable for use in Flow Cytometry, Western Blot, Neutralization. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50-1:100 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice