SCF Receptor (Stem Cell Factor Receptor, SCFR, SCF-R, C-kit, CD117)

Size

£691.00

SKU:: 216921
Purity:: Purified by Protein G affinity chromatography from culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human SCF-R EC domain.
Clone:: 14L825
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 200ul of sterile PBS.
Extra Details:: The c-kit proto-oncogene encodes a transmembrane receptor with tyrosine kinase activity, c-kit (CD117), also known as stem cell factor receptor (SCFR), which is closely related to the platelet-derived growth factor receptor family. The c-kit oncoprotein plays a role during normal hematopoiesis, gametogenesis and melanogenesis. It is expressed in among others normal breast epithelium, melanocytes, mast cells and glial cells. Defects in c-kit are a cause of several diseases, such as gastrointestinal stromal tumor (GIST), and testicular germ cell tumor. Also acute myelogenous leukemia (AML), a malignant disease in which hematopoietic precursors are arrested in an early stage of development, is related to mutation in c-kit. As a result, the antibody to CD117 is suitable the characterization of certain leukemias. Applications: Suitable for use in Western Blot and Neutralization. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice