NKp46 (NCR1, Natural Cytotoxicity Receptor)

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£691.00

SKU:: 216856
Purity:: Purified by Protein G affinity chromatography from culture supernatant
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human NKp46
Clone:: 14L760
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 200ul sterile PBS.
Extra Details:: NKp30/NCR3, NKp44/NCR2, and NKp46/NCR1 are termed natural cytotoxicity receptors (NCR). These receptors are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp44 is induced upon activation of resting NK cells with IL-2 and can bind to viral hemagglutinins. NK-mediated dendritic cell (DC) recognition is highly dependent on engagement of NKp30 and may result in lysis of the DC. Applications: Suitable for use in Flow Cytometry, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50-1:100 Western Blot: 1:500-1:1000 Immunohistochemistry (Frozen): 1:20-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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