216748
ITGB7 (Integrin B7, Integrin beta-7)
Size
£889.00
- SKU:
- 216748
- Application:
- Flow Cytometry
- Purity:
- Purified by Protein G affinity chromatography from culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rat
- Immunogen:
- Myeloid leukemia cell line (TK-1)
- Clone:
- 14L652
- Format:
- Supplied as a lyophilized powder in PBS. No preservative added. Reconstitute with sterile PBS.
- Extra Details:
- Integrin b7 is a 130kD glycoprotein, also known as integin bp. It is a member of the Ig superfamily. In association with integrin a4 or aE chain, b7 forms a4/b7 or aE/b7 heterodimer. a4/b7 (CD49d/b7, LPAM-1) is expressed on majority of peripheral lymphocytes, small subsets of thymocytes and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion, some hematopoietic progenitor cells migration. aE/b7 (CD103/b7, aIEL/b7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/b7 complex is thought to play a role in lymphocyte retention via interaction with its ligand E-Cadherin. Applications: Suitable for use in Flow Cytometry and Blocking. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Endotoxin: <0.002EU/ug Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice