Interleukin 1 Receptor Accessory Protein-like 1 (IL-1 R9, TIGIRR-1)

Size

£761.00

SKU:: 216652
Purity:: Purified by Protein G affinity chromatography from culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human IL-1 R9
Clone:: 14L556
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 200ul sterile PBS.
Extra Details:: The Interleukin 1 receptor family comprises at least nine members. All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor) signaling domain that is also conserved in the Toll-like receptor family. A subtype of the IL-1 R family, SIGIRR (single Ig domain-containing IL-1 R-related molecule) differs from the other nine members by having only one Ig domain. Interleukin 1 receptor accessory protein-like 2 (IL-1 RAPL2), also known as TIGIRR-1 and IL-1 R9, is a member of the IL-1 RI-like family of the IL-1 R/Toll-like receptor superfamily. IL-1 RAPL2 is a type I transmembrane protein that contains three Ig-like domains in its extracellular region and one intracellular TIR domain. IL-1 RAPL2 is expressed in the central nervous system, and its deletion is associated with some forms of X-linked mental retardation. An alternately spliced variant lacks the transmembrane and cytoplasmic regions. Within their extracellular domains, mouse IL-1 RAPL2 shares 99% amino acid sequence identity with human IL-1 RAPL2. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-2000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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