216643
Insulin-like Growth Factor-I (IGF-I, Insulin-like Growth Factor 1)
Size
£691.00
- SKU:
- 216643
- Application:
- WB
- Purity:
- Purified by Protein G affinity chromatography from culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Hamster
- Immunogen:
- Recombinant protein corresponding to mouse expressed in Insulin-like growth factor-I.
- Clone:
- 14L547
- Format:
- Supplied as a lyophilized powder in PBS. Reconstitute with 200ul sterile PBS.
- Extra Details:
- Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland under the stimulation control of hypothalamic factor GH Releasing Hormone (GHRH). GH acts directly and indirectly through Insulin-like Growth Factor-1 (IGF-1). Together GH and IGF promote mammalian growth and influence regulation of metabolism. In addition, the GH/IGF-1 axis has been shown to actively regulate lifespan in worms, flies and mice. However, it remains to be determined if the GH/IGF-1 axis has an equal influence on human longevity. Secretion of human GH progressively declines with age and is paralleled by decreased levels of IGF-1. GH/IGF-1 exert potent effects on the central nervous system, modulating plasticity and function. Age-related depletion of GH/IGF-1 has been associated with increased vulnerability to the development of cognitive and sleep disorders. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice