216568
GITR (Glucocorticoid-induced TNFR-related Gene, TNFSF18, AITR)
Size
£889.00
- SKU:
- 216568
- Application:
- Flow Cytometry
- Purity:
- Purified by Protein G affinity chromatography from culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rat
- Immunogen:
- Mouse CD25+CD4+ T cells
- Clone:
- 14L472
- Format:
- Supplied as a lyophilized powder from PBS. No preservative added. Reconstitute with 1ml sterile PBS.
- Extra Details:
- GITR, glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Treg cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+CD4+ T reg cells. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response. Applications: Suitable for use in Flow Cytometry and Blocking. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Endotoxin: <0.002EU/ug Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice