216338
CD8a
Size
£889.00
- SKU:
- 216338
- Application:
- Flow Cytometry
- Purity:
- Purified by Protein G affinity chromatography from culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rat
- Immunogen:
- Mouse CD8+ Cells
- Clone:
- 14L242
- Format:
- Supplied as a lyophilized powder in PBS. No preservative added. Reconstitute with sterile PBS.
- Extra Details:
- CD8 consists of disulfide-linked a and b chains that form the a(CD8a)/b(CD8b) heterodimer and a/a homodimer. CD8a is a 34kD protein that belongs to the immunoglobulin family. The CD8 a/b heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR a/b T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 a/a homodimer is expressed on a subset of g/d TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. Applications: Suitable for use in Blocking of Cytotoxicity, Cell depletion and Depletion of CD8a+ cells. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Endotoxin: <0.002EU/ug Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice