CD31 (PECAM-1)

Size

£889.00

SKU:: 216289
Purity:: Purified by affinity chromatography from tissue culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rat
Immunogen:: Mouse endothelial membrane protein.
Clone:: 2A14
Format:: Supplied as a liquid.
Extra Details:: CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a 140kD type I integral membrane glycoprotein that is expressed at high levels on early and mature endothelial cells, platelets, and most leukocyte subpopulations. The expression on endothelial cells is concentrated at junctions between adjacent cells. CD31 is also expressed on a major population of macrophage/dendritic cell precursors in the bone marrow. PECAM-1 is known to have various roles in vascular biology including angiogenesis, platelet function, and thrombosis. It is a mechanosensor of endothelial cell response to fluid shear stress and it is involved in the regulation of leukocyte migration through venular walls. Applications: Suitable for use in Inhibition. Other applications not tested. Recommended Dilution: Inhibition: Inhibiting PECAM-1 tyrosine phosphorylation level of murine endothelial cells. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice