CD126 (IL-6R alpha chain)

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£889.00

SKU:: 216246
Purity:: Purified by Protein G affinity chromatography from culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rat
Immunogen:: Recombinant protein corresponding to mouse CD126
Clone:: 14L150
Format:: Supplied as a lyophilized powder in PBS. No preservative added. Reconstitute with sterile PBS.
Extra Details:: CD126 is an 80kD IL-6 receptor a chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor b chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The b chain (gp130, CD130) does not bind IL-6 by itself, but associates with the a-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor stimulation and differentiation. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Blocking. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Endotoxin: <0.002EU/ug Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice