BMP2 (Bone Morphogenetic Protein 2, BMP-2)

Size

£704.00

SKU:: 216155
Purity:: Purified by Protein G affinity chromatography from culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human BMP-2
Clone:: 14L59
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 200ul sterile PBS.
Extra Details:: BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. It can induce bone formation and regeneration during early embryonic development. BMP-2 is synthesized as large precursor molecule firstly and the mature protein is secreted by proteolytic cleavage. Natural mature BMP-2 monomer has 114 amino acid residues and has no biological function unless it turns into dimmer. It’s assumed that mature BMP-2 forms a cysteine knot with seven conserved cysteine residues. The active form can consist of a dimmer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1000 Immunohistochemistry: 1:20-100 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice