216134
Angiopoietin-like protein 2 (ANGPTL2)
Size
£748.00
- SKU:
- 216134
- Application:
- WB
- Purity:
- Purified by Protein G affinity chromatography from culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to human Angiopoietin-like protein 2.
- Clone:
- 14L38
- Format:
- Supplied as a lyophilized powder from PBS. Reconstitute with 200ul sterile PBS.
- Extra Details:
- Angiopoietins, Ang-1, Ang-2, and Ang-3 (mouse)/Ang-4 (human), are natural ligands of the Tie-2 receptor tyrosine kinase, which is expressed primarily on endothelial cells and early hematopoietic cells. These proteins are important modulators of angiogenesis and maintenance of vascular integrity. Tie-1 may also act as an angiopoietin receptor, possibly in complex with Tie-2. Two domains characterize the angiopoietin family of proteins: an N-terminal coiled-coil domain that mediates homo-oligomerization, and a C-terminal fibrinogen-like domain that binds Tie-2. Angiopoietin/Tie receptor signaling cascades are involved in fundamental angiogenesis events including vascular stabilization and remodeling, as well as recruitment of pericytes and smooth muscle cells. In addition, since an adequate blood supply is required for tumor growth, Angiopoietin/Tie receptor signaling is believed to play an important role in many cancer pathologies. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice