Thyroid Stimulating Hormone (TSH)

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£748.00

SKU:: 216054
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human TSH.
Clone:: 14J57
Format:: Supplied as a lyophilized powder in 0.01M PBS, pH 7.2. Reconstitute with ddH2O.
Extra Details:: Thyroid stimulating hormone is secreted by pituitary gland in response to the stimulation of Thyrotropin Releasing Hormone (TRH) produced by hypothalamus. TSH binds to the TSH receptors on the surface of the follicular cells in thyroid and stimulates the production of thyroid hormones (T4 and T3). TSH, T3 and T4 play an important role in normal growth, brain development in young children, and regulate the metabolism in adults. TSH secretion is increased when T3 and T4 are insufficient. Elevated TSH, but low T3 and T4 levels indicate that thyroid cannot produce thyroid hormones at a normal rate and the condition is called hypothyroidism. If T3 and T4 levels are high when TSH is at a low level, it indicates that thyroid is producing abnormally large amount thyroid hormones, and the condition is called hyperthyroidism which is manifested by hypermetabolic symptoms. TSH has an alpha subunit that is identical to the one in other glycoprotein hormones such as LH, FSH and HCG. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice