5-HT4 Receptor (HTR4, 5-HT4, 5-HT4R, 5-HT-4, 5HT4 Receptor, 5-hydroxytryptamine 4 Receptor, 5-hydroxytryptamine Receptor 4, Serotonin 5-HT-4a Receptor, Serotonin Receptor 4, Cardiac Serotonin 4 Receptor, Serotonin 5-HT-4 Receptor)

Size

£709.00

SKU:: 215514
Application:: IHC-Fr
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 16aa from human 5HT4 Receptor at Cytoplasmic Domain.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry(Paraffin): 5-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.