Resistin, Recombinant, Human (FIZZ3, HXCP1, RSTN)

Size

£307.00

SKU:: 215109
Molecular Weight:: 19.5
Purity:: ≥98% (SDS-PAGE, HPLC).. Endotoxin: ≤ 0.1ng/ug (1EU/ug).
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder with no additives. Reconstitute with sterile, distilled water to a concentration of 0.1-1mg/ml.
Extra Details:: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMα, RELMβ, and RELMγ, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant human Resistin is a 19.5kD, disulfide-linked, homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond. Recombinant protein corresponding to human Resistin expressed in E. coli. Molecular Weight: ~19.5kD Biological Activity: Determined by its ability to stimulate lipolysis in cultured human adipocytes. (Ort, T. et al. Endocrinology; 46(5):2200-9) Amino Acid Sequence (Monomer): SSKTLCSMEE AINERIQEVA GSLIFRAISS IGLECQSVTS RGDLATCPRG FAVTGCTCGS ACGSWDVRAE TTCHCQCAGM DWTGARCCRV QP Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice