CD1d (Antigen-Presenting Glycoprotein CD1d)

Size

£869.00

SKU:: 214593
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Rat CD1d-transduced M12.4.1.C3 cells. Epitope: extracellular domain
Clone:: WTH-1
Format:: Supplied as a liquid in PBS. No preservative added.
Extra Details:: Antigen-presenting glycoprotein CD1d (UniProt Q63493; also known as CD1D antigen, CD1d1 antigen, T-cell surface glycoprotein CD1d) is encoded by the Cd1d (also known as Cd1d1) gene (Gene ID 25109) in rat species. CD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands (e.g. glycolipids) to natrual killer T (NKT) cells. NKT cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological conditions. In additon to hematopoietic cells, CD1d protein is also reported to be detected in non-lymphatic tissues in rat, such as the exocrine pancreas and Paneth cells. CD1d is initially produced with a signal peptide sequence (aa1-17), the removal of which yields the mature CD1d with a large extracellular region (aa18-304), a transmembrane domain (aa305-325), and a short cytoplasmic tail (aa326-336). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry and Activity Assays. Other applications not tested. Recommended Dilution: Flow Cytometry: 1ug detected CD1d in rat thymocytes and splenocytes. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice