Tripolin A ((3E)-3-[(2,5-Dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one)

Size

£320.00

SKU:: 207427
Molecular Weight:: 253.3
Purity:: ≥98% (HPLC, NMR)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1148118-92-6
Format:: Supplied as a yellow solid.
Extra Details:: Specific non-ATP competitive Aurora A kinase inhibitor. Does not significantly inhibit Aurora B kinase in mammalian cells. Reduces localization of pAurora A on spindle microtubules (MTs), affects centrosome integrity, spindle formation and length and MT dynamics in interphase. Sequence: [(3E)-3-[(2,5-Dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one] Solubility: DMSO (10mg/ml) Molecular Weight: ~253.3 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.