207297
Necrostatin-1
Size
£251.00
- SKU:
- 207297
- Molecular Weight:
- 259.3
- Purity:
- ≥98% (HPLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 4311-88-0
- Format:
- Supplied as an off-white to yellow solid.
- Extra Details:
- Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. CAS Number: 4311-88-0 Alternate Names: Nec-1; MTH-Trp; MTH-DL-Tryptophan; Methyl-thiohydantoin DL-tryptophan; 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone Molecular Formula: C₁₃H₁₃N₃OS Solubility: DMSO, ethanol or dimethylformamide. Sparingly soluble in aqueous buffers. For a maximum solubility in aqueous buffers, 207297 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. The solubility is ~0.5mg/ml in a 1:1 solution of DMF:PBS (pH 7.2). Store aqueous solutions not longer than one day. Note: In solution the product slightly tautomerizes. In polar solvents there is more enol form while in non-polar solvents there is more keto form. Molecular Weight: 259.3 Purity: ≥98% (HPLC) Appearance: Off-white to yellow solid. Storage and Stability: Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice