207272
Mannosylceramide, alpha
Size
£384.00
- SKU:
- 207272
- Molecular Weight:
- 858.3
- Purity:
- ≥95% (TLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 320610-63-7
- Format:
- Supplied as a white to off-white solid.
- Extra Details:
- Natural killer T cells (NKT cells) are important regulators of the immune system. They share properties of both innate as well as adaptive immunity. They express T cell receptors (TCR) on their surface consisting of an invariable α-chain and a somewhat variable β-chain. The majority of NKT cells express the invariable α-chain Vα14-Jα18 (Vα14) in mouse or its homolog in humans Vα24-Jα18 (Vα24). Vα14 NKT cells recognize α-GalCer presented by CD1d. NKT cells expressing the invariant Vα19-Jα26 TCR α-chain (Vα19 NKT cells) have been found in peripheral blood lymphocytes and in the liver. They recognize α-ManCer presented by MR1 (Major histocompatibility complex, class I-related) and respond with production of large amounts of immunoregulatory cytokines. Synonyms: α-ManCer; α-Mannosyl Ceramide; (2S,3S,4R)-2-Amino-N-hexacosanoyl-1-O-(α-D-mannopyranosyl)-1,3,4-octadecanetriol; α-D-Galactopyranoside CAS No: 320610-63-7 Molecular Formula: C50H99NO9 Solubility: Pyridine or warm DMSO Molecular Weight: 858.3 Appearance: White to off-white solid Purity: ≥95% (TLC) Storage and Stability: Store at -20°C. After reconstitution, prepare aliquots and store at -20°C. Aliquot into glass vials. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice