207236
IL-24 Fc, Recombinant, Human, aa53-207 (Interleukin-24, MDA7, ST16)
Size
£594.00
- SKU:
- 207236
- Purity:
- ~98% (SDS-PAGE)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Supplied as a lyophilized powder in PBS. Reconstitute with 250ul sterile PBS.
- Extra Details:
- IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumor suppressing protein. IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. It is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. IL-24 has antiproliferative properties is inhibiting angiogenesis and may contribute to terminal cell differentiation. Source: Recombinant protein corresponding to aa53-207 from human IL-24, fused to the N-terminus of the Fc region, expressed in CHO cells. Endotoxin: ~0.06EU/ug protein (LAL test; Lonza) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice