207101

CD134: (Human):Fc (Human), Recombinant, aa29-216 (OX40, Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4, ACT35, TXGP1L)

Size

£512.00

SKU:: 207101
Purity:: ≥98% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 50ul sterile ddH2O. Add 1X PBS to the desired protein concentration.
Extra Details:: CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells. Source: Recombinant protein corresponding to aa29-216 from human CD134, fused to the N-terminus of the Fc region of human IgG1, expressed in CHO cells. Biological Activity: Measured by its binding ability in a functional ELISA. Endotoxin: ~0.06EU/ug protein (LAL test; Lonza) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice