207066
Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A)
Size
£247.00
- SKU:
- 207066
- Molecular Weight:
- 792
- Purity:
- ≥98%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 104987-12-4
- Format:
- Supplied as a white to off-white solid.
- Extra Details:
- Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Synonyms: Immunomycin; FK520; Analog of FK-506; FR-900520; L-683590; NSC 106410; WS 7238A CAS Number: 104987-12-4 Source: Streptomyces sp. Formula: C43H69NO12 Solubility: DMSO or ethanol Molecular Weight: 792.0 Identity: Determined by MS and IR. Purity: ≥98% Appearance: Supplied as a white to off-white solid. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice