207035
Aftin-4 (N6-Methyl-(R)-roscovitine, Amyloid-beta Forty-Two Inducer 4)
Size
£258.00
- SKU:
- 207035
- Molecular Weight:
- 368.5
- Purity:
- ≥98% (HPLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 866893-90-5
- Format:
- Supplied as a white to off-white solid.
- Extra Details:
- Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase. CAS Number: 866893-90-5 Formula: C20H28N6O Solubility: DMSO or ethanol Molecular Weight: 368.5 Method for Determining Identity: Proton NMR Purity: ≥98% (HPLC) Appearance: Supplied as a white to off-white solid. Storage and Stability: May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Keep cool and dry. Protect from light and moisture. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice