Presenilin-1 (Not for Export EU)

Size

£588.00

SKU:: 171724
Purity:: Neat serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to aa14-33, AQMSEDNHLSNTVRSQNDNR, from human presenilin.
Format:: Supplied as a liquid in 0.09% sodium azide.
Extra Details:: Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer's disease, probably functioning through its associated g-secretase activity for amyloid-b protein processing. Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed N-terminus (~34kD) and C-terminus (~20kD) fragments. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA: 1:5000 Immunohistochemistry (paraffin): 1:100 Immunohistochemistry (frozen): 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.