WNK1 (Erythrocyte 65kD Protein, HSAN2, KIAA0344, Kinase Deficient Protein, HWNK1, PHA2C, PRKWNK1, PSK, HSN2, KDP)

Size

£735.00

SKU:: 171413
Application:: IHC-Fr
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 17aa from the C-terminus of human WNK1. Species Sequence Homology: bat, elephant, gibbon, gorilla, hamster, equine, marmoset, monkey, mouse, opossum, panda, rabbit, rat (100%); porcine (94%); bovine (88%).
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: WNK1, a WNK type protein kinase, contains a small N-terminal domain followed by a kinase domain and a long C-terminal tail. The protein is cytoplasmic and has been shown to regulate both the c-Jun N-terminal kinase pathway and the actin cytoskeleton in vitro. WNK1 has been identified as the gene mutant in pseudohypoaldosteronism type 2, also known as Gordon hyperkalemia-hypertension syndrome, which is a rare autosomal dominant form of volume-dependent, low-renin hypertension. Disease-causing mutations are large intronic deletions that increase WNK1 expression. At least two variants of WNK1 are produced by alternative splicing. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5-7.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice