Thromboxane B2 11-Dehydrogenase (ALDH1, Retinal Aldehyde Dehydrogenase) (Not for Export EU)

Size

£735.00

SKU:: 171341
Application:: WB
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Thromboxane B2 11-dehydrogenase from human erythrocytes
Format:: Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.
Extra Details:: Aldehyde dehydrogenase (ALDH) is an enzyme that catalyzes the oxidation of various aldehydes to their corresponding carboxylic acid. There are 19 human ALDH isozymes, which have varying expression levels, subcellular localization, tissue distribution, cofactor preference, and substrate specificity. ALDH exists as a homodimer or homotetramer and is composed of a cofactor-binding domain, which binds NAD+ or NADP+, a catalytic domain, and an oligomerization domain. ALDH has protective roles in alcohol detoxification and oxidative stress, regulatory roles in the function of normal stem cells and tumor-initiating stem-like cells, and a biosynthetic role in the formation of retinoic acid.,1 It also catalyzes the catabolism of thromboxane B2 (TXB2) to 11-dehydro TXB2. Mutations in the genes encoding ALDH isozymes are associated with a variety of human conditions, including alcohol intolerance, Parkinson's disease, and gout. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice