TAOK1 (MAP3K16, MARK Kinase, HKFC-B, KFC-B, TAO Kinase 1, TAO1, MARKK, PSK2, HTAOK1, KIAA1361, Kinase from chicken Homolog B, PSK-2, Rat TAO1, STE20-like Kinase PSK2, Sulu3)

Size

£709.00

SKU:: 171324
Application:: IHC-Fr
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 15aa from the internal region of human TAOK1. Species sequence homology: bat, bovine, chicken, canine, xenopus, hamster, equine, mouse, porcine, rabbit and rat.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: TAOK1 is a TAO type protein kinase. TAOK1 enhances microtubule dynamics through the activation of MARK (microtubule affinity regulating kinase) that leads to phosphorylation and detachment of tau and other MAPs from microtubules causing destabilization. TAOK1 also interacts via downstream targets such as JNK and ROCK-1 to regulate apoptotic morphology associated with the execution phase of apoptosis, which involves reorganization of the actin cytoskeleton. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.