170892
KCNMA1 (BA205K10.1, BKCA alpha Subunit, BK Channel, BKCA alpha, BKTM, HSlo, K(VCA)alpha, KCa1.1, Maxi-K Channel HSLO, MaxiK, KCNMA, SAKCA, SLO-ALPHA, Slowpoke Homolog, Stretch-activated Kca Channel, Slo Homolog, BK Channel alpha Subunit, Maxi K Channel, MSlo, MSLO1, SLO, SLO1)
Size
£709.00
- SKU:
- 170892
- Application:
- IHC-Fr
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 15aa from the internal region of human KCNMA1.
- Format:
- Supplied as a liquid in PBS, 0.09% sodium azide.
- Extra Details:
- Maxi-K channels, also known as BK channels, consist of a pore-forming alpha subunit and a regulatory beta subunit, which confers the channel with a higher calcium sensitivity. Homologs of the Drosophila melanogaster calcium-activated potassium channel gene, slowpoke, the mouse and human genes generate multiple transcripts by alternative splicing. The splice variants differ significantly in their Ca2+ sensitivity, suggesting a broad functional role for these channels in the regulation of neuronal excitability. The alpha-subunit shows a tissue distribution different to that of the beta-subunit, and in many tissues there may be no association of alpha-subunits with beta-subunits. The beta-subunits can play a functional role in the regulation of neuronal excitability by tuning the Ca2+ and/or the voltage dependence of alpha-subunits (Tseng-Crank et al., 1996). Maxi-K channels may have potential utility of gene therapy for urinary incontinence and erectile dysfunction. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice