HTR2B (5-hydroxytryptamine Receptor 2B, 5-HT-2B, 5-HT2B, 5-HT(2B), Serotonin Receptor 2B)

Size

£709.00

SKU:: 170861
Application:: IHC-Fr
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 15aa from 2nd extracellular domain of human 5HT2B Receptor. Species sequence homology: bat and bovine (90%).
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: 5-HT2B, a Serotonin Receptor, activates phospholipase C upon binding serotonin, which results in a rise in intracellular calcium. It is known that 5-HT2B regulates cardiovascular function during development and in adulthood; mice lacking functional 5-HT2B receptors died of heart defects during gestation or neonatally, and adult mutant mice displayed cardiopathy, including myocyte disarray and ventricular dilation. Applications: Suitable for use in Immunohistochemistry. Not suitable for Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 4-6ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.