170830
GRM5 (GPRC1E, MGLUR5, Mglur5b, MGlu5)
Size
£735.00
- SKU:
- 170830
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 16aa from the C-terminus of human GRM5/MGLUR5. Species sequence homology: rabbit.
- Format:
- Supplied as a liquid in PBS, 0.09% sodium azide.
- Extra Details:
- Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia. Summary of expresson: GRM5 has been reported to be expressed in various regions of the brain as well as in the spinal cord and dorsal root ganglia. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 16ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice