170461
ERR Beta (ESRRB, DFNB35, ERRb, ERRbeta-2, ESRL2, Estrogen Receptor-like 2, ERR-beta, ERRB2, NR3B2, Nuclear Receptor ERRB2, Orphan Nuclear Receptor, ERR beta-2, ERR2, Estrogen-related Receptor 2, Estrogen-related Receptor beta, Steroid Hormone Receptor ERR2)
Size
£735.00
- SKU:
- 170461
- Application:
- IHC-Fr
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 16aa from the N-terminus of human ESRRB/ERR Beta. Species sequence homology: mouse and rat.
- Format:
- Supplied as a liquid in PBS, 0.09% sodium azide.
- Extra Details:
- Estrogen-related receptor beta (ERR beta) a NR3 Steroid Receptor, has been shown to affect early placental development. ERR beta also can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). ERR beta binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). ERR beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice