ADAMTS5 (ADAMTS5, Aggrecanase-2, ADAM-TS 11, ADAM-TS5, ADAMTS-11, ADAMTS11, ADAM-TS 5, ADAMTS-5, ADMP-2, ADMP2)

Size

£735.00

SKU:: 170136
Application:: IHC-Fr
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 16aa from the C-terminus of human ADAMTS5. Species sequence homology: bat, chicken, canine, hamster, equine, mouse, porcine and rat.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 2-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.