5HT2C (HTR2C, 5-HT-1C, 5-HT1c Receptor, 5HT-1C, 5-HT2C, 5-HT2c Receptor, 5HT2C Receptor, 5-HT-2C, 5-HT1C, 5-HTR2C, HTR1C, Serotonin 5-HT-1c Receptor, Serotonin Receptor 2C, Serotonin 1c Receptor, Serotonin 5-HT-2C Receptor, Serotonin 2c Receptor)

Size

£709.00

SKU:: 170119
Application:: IHC-Fr
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 16aa from 3rd cytoplasmic domain of human 5HT2C. Species sequence homology: equine and porcine.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: 5-HT2C, a Serotonin Receptor previously termed 5-HT1C, activates phospholipase C, resulting in a transient increase in intracellular calcium and activation of protein kinase C. Mutant mice lacking functional 5-HT2C receptor are overweight due to abnormal feeding behavior and are prone to epileptic seizures. Therefore, agonists of the 5-HT2C receptor such as m-chlorophenylpiperazine (mCPP) may be potential drugs for the treatment of obesity. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 2.6ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.