168375
MPYS (Transmembrane protein 173, TMEM173, ERIS, MITA, STING, Stimulator of interferon genes protein, hSTING, Mediator of IRF3 activation)
Size
£832.00
- SKU:
- 168375
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide near the C-terminus of human MPYS.
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
- Extra Details:
- MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist. Applications: Suitable for use in Immunocytochemistry, ELISA and Western Blot. Other applications not tested. Recommended Dilution: Immunocytochemistry: 5ug/ml ELISA: 1:10,000-1:40,000 Western Blot: 1-2ug/ml, a band of ~37-42kD is expected Optimal dilutions to be determined by the researcher. Positive Control: A20 cell lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice