Tubacin

Size

£320.00

SKU:: 167986
Molecular Weight:: 721.86
Purity:: ≥98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 537049-40-4
Format:: White to off-white powder
Extra Details:: Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50=4nm). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits a-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of a-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated a-tubulin deacetylation in mammalian cells. Synonyms: rel-N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide CAS Number: 537049-40-4 Molecular Formula: C₄₁H₄₃N₃O₇S Molecular Weight: 721.86 Appearance: White to off-white powder Purity (HPLC): ≥98% Melting Point: 155-157°C Solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated) Storage: -20°C