Integrin a2b (CD419, CD41, GP2B, GPIIb, GTA, HPA3, ITGA2b) (APC)

Size

£780.00

SKU:: 167667
Application:: Flow Cytometry
Purity:: Purified by Protein G affinity chromatography from hybridoma culture supernatant.
Storage Conditions:: 4°C Do Not Freeze
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Heterodimer of human Integrin alpha 2B (Leu32-Arg993) and human Integrin beta 3 (Gly27-Asp718).
Clone:: 745201
Format:: Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with Allophycocyanin (APC).
Extra Details:: Integrin a2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide- linked chains (114kD and 22kD) during transit through the Golgi. Integrin a2b associates with Integrin b3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. Integrin a2b is required for platelet aggregation and defects lead to disorders of coagulation. Within the extracellular domain, human Integrin a2b shares 80% and 78%aa sequence identity with mouse and rat Integrin a2b, respectively. This clone is specific for Integrin a2b/CD41 by direct ELISA. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul labels 10e6 cells Optimal dilutions to be determined by the researcher. Absorption: 620-650nm Emission: 660-670nm Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.

Shipping Conditions:: Blue Ice