TARP Gamma2-4-8 (Stargazin) (Voltage-dependent calcium channel gamma-2 subunit, Neuronal voltage-gated calcium channel gamma-2 subunit, Stargazin and Stg)

Size

£626.00

SKU:: 167613
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Fusion protein amino acids 203-323 (Cytoplasmic Cterminus) of rat TARPGamma2, Accession# Q71RJ2
Clone:: S245-36
Format:: Supplied as a liquid in PBS pH7.4, 50% glycerol.
Extra Details:: Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival. Applications: Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: 1ug/ml was sufficient for detection of TARP Gamma2/4/8 in 20ug of rat brain lysate by Western Blot using Goat anti-mouse IgG:HRP as the secondary antibody. Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice