Aminoacyl tRNA Synthase Complex Interacting Multifunctional Protein 1 (AIMP1, SCYE1, Aminoacyl tRNA Synthetase Complex-interacting Multifunctional Protein 1, ARS-interacting Multifunctional Protein 1, EMAP2, EMAPII, Endothelial Monocyte-activating Polypeptide 2, Endothelial-monocyte Activating Polypeptide II, HLD3, Multisynthase Complex Auxiliary Component p43, Multisynthetase Complex Auxiliary Component p43, p43, Small inducible Cytokine Subfamily E, Member 1 (endothelial monocyte-activating))

Size

£642.00

SKU:: 167344
Purity:: Purified by ammonium sulfate precipitation.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Peptide with sequence NNDAVLKRLEQK-C, from the N-terminal domain of the protein sequence (NP_004748.2, NP_001135888.1).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Extra Details:: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Western Blot: 0.3-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice