ABHD14B (NACHT, leucine rich repeat and PYD containing 10, NACHT, LRR and PYD containing protein 10, NACHT, LRR and PYD domains-containing protein 10, NACHT/LRR/pyrin domain-containing protein 10, Nalp10, Napl10, Neuronal apoptosis inhibitor protein 10, NLR family, Pyrin domain containing 10, Nlrp10, PAN5, Pynod)

Size

£642.00

SKU:: 167340
Purity:: Purified by ammonium sulfate precipitation.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Peptide with sequence NDLEENSFKTLKFH-C, from the N-terminal domain of the protein sequence (NP_780741.1).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Extra Details:: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Applications: Suitable for use in Immunofluorescence, ELISA and Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence: 0.5-1ug/ml ELISA: 1:128,000 Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.