167133
Zymostenol
Size
£322.00
- SKU:
- 167133
- Molecular Weight:
- 386.65
- Purity:
- ≥95%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 566-97-2
- Format:
- Crystalline solid
- Extra Details:
- Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.1 It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ) with an EC50 value of 1uM in a RORγ coactivator recruitment assay in the presence of ursolic acid. It increases the number of myelin basic protein-positive oligodendrocytes generated from oligodendrocyte precursor cells in vitro.2 Zymostenol accumulates in cells following administration of microsomal antiestrogen-binding site (AEBS) ligands, such as tamoxifen, which are associated with cell differentiation and a protective type of autophagy.3,4 When used alone at a concentration of 20uM, zymostenol halts the cell cycle at the G0/G1 phase and increases the levels of free sterols, esterified sterols, and triacylglycerols in MCF-7 cells.3 Synonyms: 5α-Cholest-8-en-3β-ol; 3β-Hydroxy-5α-cholest-8(9)-ene; Dihydrozymosterol; Δ8-Cholestenol; (3β,5α)-Cholest-8-en-3-ol CAS No: 566-97-2 Molecular Formula: C27H46O Molecular Weight: 386.65 Appearance: Crystalline solid Purity: ≥95% Solubility: DMF, Ethanol Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with DMF or Ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Ambient