SAR131675

Size

£460.00

SKU:: 166482
Molecular Weight:: 358.39
Purity:: ≥97%
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1092538-80-1
Format:: Supplied as an off-white to pale yellow solid.
Extra Details:: SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD. Synonyms: 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide CAS No: 1092538-80-1 Molecular Formula: C₁₈H₂₂N₄O₄ Molecular Weight: 358.39 Appearance: White to Pale Yellow Solid Melting Point: ≥206°C (dec.) Solubility: DMSO (Slightly) Method for Determining Identity: Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: SiO2; Dichloromethane: Methanol = 9:1; Visualized with UV and KMnO4; Single spot, Rf=0.45 Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.