PHA 767491 Dihydrochloride Salt

Size

£409.00

SKU:: 165897
Molecular Weight:: 286.16
Storage Conditions:: RT/4°C
Supplier:: United States Biological
Format:: Supplied as a Pale Yellow Solid
Extra Details:: A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2). Melting Point: >300°C Solubility: DMSO, Water