164462
Ibrutinib, Free Base
Size
£221.00
- SKU:
- 164462
- Molecular Weight:
- 440.5
- Purity:
- ≥99% (HPLC), ≥99% (TLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 936563-96-1
- Format:
- White to off-white crystalline powder
- Extra Details:
- Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM in cellular assay with Ramos cells. It demonstrated preference toward BTK over closely related kinases, blocked B cell function and BTK-dependent processes, and demonstrated clear efficacy in a mouse arthritis model. Young P.R., et al. "Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase." ChemMedChem. 2: 58-61 (2007). Appearance: White to off-white crystalline powder Purity: ≥99% (HPLC) ≥99% (TLC) Solubility: DMSO Melting Point: 150-154°C
- Shipping Conditions:
- Ambient