161268
RS-1
Size
£236.00
- SKU:
- 161268
- Molecular Weight:
- 524.23
- Purity:
- ≥95%
- Storage Conditions:
- RT/4°C
- Supplier:
- United States Biological
- CAS Number:
- 312756-74-4
- Format:
- Supplied as a brown solid
- Extra Details:
- High affinity RAD51 activator (Kd range = 48-107nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo. RS-1 is an activator of DNA repair protein RAD51 (Kd = 48-107 for human RAD51 with different cofactors present).1 It stimulates homologous strand assimilation activity at least 5- to 11-old, enhancing homologous recombination activity of hRAD51.1 RS-1 is a potent enhancer of CRISPR-mediated genome editing, increasing homology directed repair 3- to 6-fold.2 It is used to increase CRISPR-mediated knock-in efficiencies in vitro and in vivo.3,2,4 Synonyms: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide CAS No: 312756-74-4 Molecular Formula: C₂₀H₁₆Br₂N₂O₃S Molecular Weight: 524.23 Appearance: Supplied as a brown solid. Purity: ≥95% Solubility: RS-1 is supplied as a crystalline solid. A stock solution may be made by dissolving the RS-1 in the solvent of choice. RS-1 is soluble in organic solvents such as DMSO and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of RS-1 in these solvents is approximately 20 and 30 mg/ml, respectively. RS-1 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, RS-1 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. RS-1 has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day. Storage and Stability: Store at room temperature. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient