4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-benzoic Acid

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£479.00

SKU:: 161168
Molecular Weight:: 443.41
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1237744-13-6
Format:: White to off-white solid
Extra Details:: A noncompetitive and voltage-independent antagonist selective for NR2C/D containing nMDA receptors (IC50 = 6, 3, 229, and >300uM for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/D containing nMDA receptors is glutamate-binding, but not glycine-binding, dependent. Represents a new class of noncompetitive subunit-selective nMDA receptor antagonists. With more than 100-fold selectivity for recombinant nMDA receptors over AMPA and kainate receptors. Synonyms: QZN-46; QNZ46; 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic Acid; NMDA Antagonist VIII; (E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid Primary Target: NMDA receptors Primary Target IC50: 6, 3, 229, and >300 →M for NR2C, NR2D, NR2A, and NR2B, respectively. CAS No: 1237744-13-6 Molecular Formula: C24H17N3O6 Molecular Weight: 443.41 Appearance: White to off-white solid Purity: ≥98% (HPLC) NMR, MS: Conforms to reference Solubility: DMSO Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.