2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

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£403.00

SKU:: 159529
Molecular Weight:: 509.73
Storage Conditions:: RT/4°C
Supplier:: United States Biological
CAS Number:: 1255580-76-7
Extra Details:: UNC0638 is a selective inhibitor of G9a and G9a-like protein (GLP), also known as EHMT1, with IC50's in the very low (<20) nM range. It also exhibits very weak activity against JMJD2E (IC50 ~4.5uM), but the selectivity for G9a and GLP is over 200-fold. UNC0638 was inactive against SUV39H1, SUV39H2, EZH2), SETD7, MLL, SMYD3, DOT1L, SETD8, PRDM1, PRMT1 and PRMT3. UNC0638 exhibits only extremely weak inhibition of DNMT1 (IC50 >100uM). Alternate Name: UNC0638 CAS Number: 1255580-76-7 Molecular Formula: C30H47N5O2 Molecular Weight: 509.73 Solubility: Soluble in DMSO purged with an inert gas, then dilute into aqueous buffer just before use. Solubility in DMSO is 20mg/ml. Biological Activity: Inhibits G9a activity with an IC50 value of <15nM in vitro. It also inhibits GLP with an IC50 value of 19nM. Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.