Il16, Recombinant, Mouse, aa22-287, His-Tag (Pro-interleukin-16, Interleukin-16, IL-16, Lymphocyte Chemoattractant Factor, LCF)

Size

£497.00

SKU:: 149786
Molecular Weight:: 29
Purity:: ~95%
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 20mM Tris, 0.5M sodium chloride, 250mM Imidazole, 5mM beta-mercaptoethanol, 10% glycerol.
Extra Details:: IL-16 was initially identified as a chemotactic cytokine, but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases. The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20kD active form that binds to and signals through CD4. Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders. At least two isoforms of IL-16 are known to exist; the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus. This recombinant protein fragment is derrived from this longer isoform. Source: Recombinant protein corresponding to mouse IL-16, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~29kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Dry Ice