MTCH2, Recombinant, Mouse, aa29-174, His-Tag (Mitochondrial Carrier Homolog 2, 2310034D24Rik, 4930539J07Rik, HSPC032)

Size

£483.00

SKU:: 149781
Molecular Weight:: 19
Purity:: ~95%
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 1X PBS, 0.1% SDS.
Extra Details:: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway. The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence. Source: Recombinant protein corresponding to mouse MTCH2, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~19kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.