Rcan2, Recombinant, Mouse, aa2-197, His-Tag (Calcipressin-2, Calcineurin Inhibitory Protein ZAKI-4, Down Syndrome Candidate Region 1-like Protein 1, Myocyte-enriched Calcineurin-interacting Protein 2, MCIP2, Regulator of Calcineurin 2, Dscr1l1, Zaki4)

Size

£632.00

SKU:: 149777
Molecular Weight:: 26
Purity:: ~95%
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 100mM sodium phosphate, 10mM Tris, 500mM sodium chloride, 25mM imidazole, 2mM magnesium chloride, 10% glycerol.
Extra Details:: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Source: Recombinant protein corresponding to mouse RCAN2 Isoform 2, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~26kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Dry Ice