IRAK1, Recombinant, Human, aa618-712, His-Tag (Interleukin-1 Receptor-associated Kinase 1, IRAK-1, IRAK)

Size

£632.00

SKU:: 149775
Molecular Weight:: 15
Purity:: ~95%
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 100mM sodium phosphate, 500mM sodium chloride, 25mM imidazole, 10% glycerol.
Extra Details:: Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF). Source: Recombinant protein corresponding to human IRAK, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~15kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Dry Ice